Lamm Centro Analisi e BiMoC (Società Scientifica Biologia Molecolare Clinica) hanno presentato un contributo per il 47° Congresso Nazionale della Società Italiana di Microbiologia che si svolgerà a Roma dal 18 al 21 Settembre 2019.

Il contributo è stato accettato per la presentazione sotto forma di Poster nell'area “Virologia”.

Di seguito l'Abstract del contributo dal titolo
High prevalence of Anelloviridae in patients with periodontal disease
1Department of Public Health and Infectious Diseases, Parasitology Section, Sapienza University, Rome, Italy; 2LAMM, BiMoC, Lucca, Italy; 3Department of Public Health and Infectious Diseases, Public Health Section, Sapienza University, Rome, Italy.
Introduction. The Anelloviridae are an emerging family of infectious agents. Their genome consists of small, single-stranded, circular, negative-sense DNA with a size of 30 nm and their virions lack envelopes. Three genera of the family Anelloviridae are identified in humans: Alphatorquevirus (Torque Teno Virus, TTV), Betatorquevirus (Torque Teno Mini Virus, TTMV), Gammatorquevirus (Torque Teno Midi Virus, TTMDV). Human Anelloviruses, especially TTV, are characterized by extremely high prevalence in the general population, with relatively uniform distribution worldwide and an apparent pan-tropism at the host level. They have been associated with various diseases, including hepatitis, cancer, respiratory diseases, hematological and autoimmune disorders, and periodontitis. Aim of this study was to investigate the evidence of the association between Anelloviridae and periodontitis. 

Materials and Methods. Literature search through PubMed, Scopus, Web of Science, GOOGLE Scholar was performed, using [(“Anellovirus” OR “Torque Teno”) AND “periodont*”] as search terms. Observational studies reporting prevalence of any type of Anelloviridae, assessed with any sampling method, in periodontitis and healthy patients were considered. Prevalence ratio (PR) with 95% confidence interval (95CI) were extracted/assessed from each selected study and the pooled PR was calculated. Sensitivity analysis to virus type also was performed.

Results. Five studies were identified, one of them (Priyanka et al. J Indian Soc Periodontol 2017) was excluded because there was not a control group. Of the included studies, two investigated two specific TTMV species (TTMV-222, Zhang et al. Sci Rep 2016 and TTMV-204, (Zhang et al. Virus Genes 2017), one investigated all the three genera (Spandole-Dinu et al. BMC Infect Dis 2018), one investigated TTV (Rotundo et al. J Periodontol 2004). In three studies the sampling methods was gingival biopsy, while Spandole-Dinu et al. performed serum samples. The pooled PRs assessed with the fixed-effects model, chosen because within-study heterogeneity was low, were: Anelloviridae 1.31 (95CI, 1.20-1.43, 4 studies); TTV 1.28 (95CI, 1.17-1.60, 2 studies); TTMV 1.37 (95CI, 1.18-1.60, 3 studies); TTMDV 1.27 (95CI, 1.13-1.42, 1 study). 

Discussion and Conclusions. This analysis was based on few studies, thus making it impossible the investigation of result robustness. The strength of the evidence is, consequently, limited. Nevertheless, periodontitis patients resulted 30% more likely to be infected with any type of Anelloviridae than healthy individuals, with few differences between genera. The present data suggest that Anelloviridae could be important periodontitis markers, or even causally associated to this disease.

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